Abstract
We developed mathematical modeling tools for mapping 3D infarct geometry from multislice late gadolinium enhancement data, allowing fusion with multislice MR tagging data, in mice with myocardial infarction. Five C57BL/6 mice were imaged at baseline, 1, 7 and 28 days after 60 min occlusion of the left anterior descending coronary artery. The 3D infarct geometry was mapped in material coordinates, and registered with 3D strain, showing permanent dysfunction in infarcted segments, intermediate function in the adjacent zone, and maintained function in the remote zone. 3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Artificial Intelligence
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Contrast Media / administration & dosage*
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Coronary Stenosis / diagnosis
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Disease Models, Animal
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Gadolinium DTPA / administration & dosage*
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Heart Rate
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Image Enhancement*
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Imaging, Three-Dimensional*
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Magnetic Resonance Imaging*
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Mice
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Mice, Inbred C57BL
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Models, Theoretical
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Myocardial Contraction
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Myocardial Infarction / diagnosis*
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Myocardial Infarction / etiology
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Myocardial Infarction / pathology
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Myocardial Infarction / physiopathology
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Myocardial Reperfusion
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Myocardial Reperfusion Injury / complications
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Myocardial Reperfusion Injury / diagnosis*
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Myocardial Reperfusion Injury / pathology
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Myocardial Reperfusion Injury / physiopathology
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Stroke Volume
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Time Factors
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Ventricular Function, Left
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Ventricular Remodeling
Substances
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Contrast Media
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Gadolinium DTPA