Highly enantioselective synthesis of beta-amino alcohols

Org Lett. 2006 Aug 3;8(16):3509-12. doi: 10.1021/ol061133d.

Abstract

[reaction: see text] N,N-Dialkyl-beta-amino alcohols derived from alpha-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Amino Alcohols / chemical synthesis*
  • Amino Alcohols / chemistry
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Stereoisomerism

Substances

  • Amino Acids
  • Amino Alcohols