New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer

Nucl Med Biol. 2006 Jan;33(1):153-8. doi: 10.1016/j.nucmedbio.2005.07.005.

Abstract

A simple, rapid and fully automated preparation of sodium [(18)F]fluoroacetate has been developed by taking advantage of the similarities between the reaction pathways of [(18)F]fluoroacetate and [(18)F]-2-fluoro-deoxyglucose (FDG). The automated synthesis of sodium [(18)F]fluoroacetate was achieved with a commercial [(18)F]FDG synthesizer, the TRACERlab MX(FDG). The method produced the desired compound in a short synthesis time (32 min) and with a high and reproducible radiochemical yield (50.2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Fluorine Radioisotopes
  • Fluoroacetates / chemical synthesis*
  • Isotope Labeling / methods*
  • Radiopharmaceuticals / chemical synthesis
  • Robotics / instrumentation*
  • Robotics / methods

Substances

  • Fluorine Radioisotopes
  • Fluoroacetates
  • Radiopharmaceuticals
  • fluoroacetic acid