Abstract
Two new thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands have been synthesized. Copper(II) and copper(I) complexes of the ligands have been prepared and characterized by X-ray crystallography. Cyclic voltammetry measurements show that the copper(II) complexes undergo quasi-reversible reductions at biologically accessible potentials. One of the ligands, bearing a pendant carboxylate arm, has been conjugated to N-alpha-(tert-butoxycarbonyl)-L-lysine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chelating Agents / chemical synthesis*
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Chelating Agents / chemistry
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Copper / chemistry*
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Crystallography, X-Ray
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Hydrazines / chemistry*
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Ligands
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Radiopharmaceuticals
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Thiosemicarbazones / chemistry*
Substances
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Chelating Agents
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Hydrazines
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Ligands
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Organometallic Compounds
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Radiopharmaceuticals
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Thiosemicarbazones
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Copper