Abstract
Cocaine is an alkaloid with psychostimulant action and high addictive potential. It possesses high affinity for the transporters of dopamine, serotonin (5-HT) and noradrenaline, and blocks reuptake of the above-mentioned monoamines. The present review summarized the contribution of 5-HT neurotransmitter system to rewarding and aversive properties of cocaine, to cocaine withdrawal and its long-term abuse. The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse.
MeSH terms
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Animals
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Brain / drug effects
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Brain / metabolism*
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Central Nervous System Stimulants / adverse effects*
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Central Nervous System Stimulants / metabolism
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Cocaine / adverse effects*
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Cocaine / metabolism
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Cocaine-Related Disorders / metabolism*
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Dopamine Plasma Membrane Transport Proteins / metabolism
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Humans
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Norepinephrine Plasma Membrane Transport Proteins / metabolism
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Receptors, Serotonin / metabolism
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins / metabolism
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Substance Withdrawal Syndrome / metabolism*
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Synaptic Transmission
Substances
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Central Nervous System Stimulants
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Dopamine Plasma Membrane Transport Proteins
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Norepinephrine Plasma Membrane Transport Proteins
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Receptors, Serotonin
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Serotonin Plasma Membrane Transport Proteins
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Serotonin
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Cocaine