Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB)

P Mäding; F Füchtner; F Wüst

doi:10.1016/j.apradiso.2005.03.005

Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB)

Appl Radiat Isot. 2005 Sep;63(3):329-32. doi: 10.1016/j.apradiso.2005.03.005.

Authors

P Mäding¹, F Füchtner, F Wüst

Affiliation

¹ Institut für Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, Postfach 510119, 01314 Dresden, Germany. p.maeding@fz-rossendorf.de

PMID: 15949940
DOI: 10.1016/j.apradiso.2005.03.005

Abstract

The three-step radiosynthesis of N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [(18)F]SFB was obtained in decay-corrected radiochemical yields of 34-38% (related to [(18)F]fluoride; n=12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93-96%.

MeSH terms

Benzoates / chemical synthesis*
Fluorine Radioisotopes / chemistry*
Humans
Isotope Labeling / methods
Positron-Emission Tomography / methods
Radiopharmaceuticals / chemical synthesis*
Succinimides / chemical synthesis*

Substances

Benzoates
Fluorine Radioisotopes
Radiopharmaceuticals
Succinimides
N-succinimidyl-4-fluorobenzoate