Sarcoidosis is a disease found in most populations worldwide, although it has a proclivity for relatively young African-American women in the United States. Although the pathogenesis is unknown, there likely are social, environmental, and genetic factors that are involved. Sarcoidosis seems to be different between whites and African Americans, with the latter population experiencing more severe and chronic disease. Improving access to care and addressing other disparities in health care may help to bridge the gap in health outcomes observed between patients.