Abstract
The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Attention Deficit Disorder with Hyperactivity / metabolism
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Central Nervous System Stimulants
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Disease
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Dopamine Plasma Membrane Transport Proteins
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Humans
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Membrane Glycoproteins / biosynthesis
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins / biosynthesis
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / metabolism*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Nervous System Diseases / metabolism*
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Neurotoxicity Syndromes / metabolism*
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Parkinson Disease / metabolism
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Substance-Related Disorders / metabolism
Substances
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Central Nervous System Stimulants
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A3 protein, human