Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases

Charlotte F J M Peeters; Lioe-Fee de Geus; Johan R Westphal; Robert M W de Waal; Dirk J Ruiter; Theo Wobbes; Wim J G Oyen; Theo J Ruers

doi:10.1016/j.surg.2004.06.004

Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases

Surgery. 2005 Feb;137(2):246-9. doi: 10.1016/j.surg.2004.06.004.

Authors

Charlotte F J M Peeters¹, Lioe-Fee de Geus, Johan R Westphal, Robert M W de Waal, Dirk J Ruiter, Theo Wobbes, Wim J G Oyen, Theo J Ruers

Affiliation

¹ Department of Pathology 437, University Medical Center, PO Box 9101, Nijmegen 6500 HB, The Netherlands. c.peeters@pathol.umcn.nl

PMID: 15674209
DOI: 10.1016/j.surg.2004.06.004

Abstract

Removal of a primary colorectal tumor resulted in an increase in metabolic activity in its liver metastasis. Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. This finding indicates that the primary tumor suppressed angiogenesis in its distant metastasis, and that removal of the primary lesion caused a flare-up in vessel neoformation and, thus, enhanced metabolic activity in its liver metastasis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Angiostatins / urine*
Colorectal Neoplasms / metabolism
Colorectal Neoplasms / surgery*
Endostatins / blood*
Fluorodeoxyglucose F18
Humans
Liver Neoplasms / diagnostic imaging
Liver Neoplasms / metabolism*
Liver Neoplasms / secondary*
Positron-Emission Tomography
Radiopharmaceuticals

Substances

Endostatins
Radiopharmaceuticals
Fluorodeoxyglucose F18
Angiostatins