Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties

J Am Chem Soc. 2005 Jan 12;127(1):58-9. doi: 10.1021/ja044293y.

Abstract

Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Adjuvants, Immunologic / chemistry*
  • Animals
  • Cations
  • CpG Islands / immunology*
  • Interferon-gamma / metabolism*
  • Interleukin-6 / metabolism
  • Kinetics
  • Lymphocytes / drug effects
  • Lymphocytes / immunology
  • Mice
  • Nanotubes, Carbon / chemistry*
  • Oligonucleotides / administration & dosage
  • Oligonucleotides / chemistry*
  • Oligonucleotides / immunology*
  • Surface Plasmon Resonance

Substances

  • Adjuvants, Immunologic
  • Cations
  • Interleukin-6
  • Nanotubes, Carbon
  • Oligonucleotides
  • Interferon-gamma