Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin

Nucl Med Biol. 2004 Nov;31(8):1005-11. doi: 10.1016/j.nucmedbio.2004.06.009.

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [(11)C]doxepin ([(11)C]DOX) to evaluate histamine H(1) receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [(11)C]DOX, estimated quantitatively with a two-compartment model, and the [(11)C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [(11)C]DOX-H1R binding.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Carbon Radioisotopes
  • Doxepin / pharmacokinetics*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Male
  • Metabolic Clearance Rate
  • Models, Biological
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacokinetics
  • Receptors, Histamine H1 / metabolism*
  • Statistics as Topic
  • Tissue Distribution

Substances

  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Histamine H1
  • Doxepin