Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine

Yuichi Kimura; Kenji Ishii; Nobuyoshi Fukumitsu; Keiichi Oda; Toru Sasaki; Kazunori Kawamura; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.005

Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine

Nucl Med Biol. 2004 Nov;31(8):975-81. doi: 10.1016/j.nucmedbio.2004.06.005.

Authors

Yuichi Kimura¹, Kenji Ishii, Nobuyoshi Fukumitsu, Keiichi Oda, Toru Sasaki, Kazunori Kawamura, Kiichi Ishiwata

Affiliation

¹ Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo 173-0022, Japan. ukimura@ieee.org

PMID: 15607479
DOI: 10.1016/j.nucmedbio.2004.06.005

Abstract

Fully quantitative analysis of the adenosine A(1) receptor (A1R) in the brain with (11)C-MPDX and positron emission tomography is reported. The kinetics is described using a two-tissue three-compartment model, and estimated binding potentials correspond well with the estimates made by Logan plot. The image of the binding potential of the MPDX is physiologically reasonable. We conclude that MPDX is applicable to the visualization of the A1Rs in the brain with Logan plot.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Algorithms
Brain / diagnostic imaging*
Brain / metabolism*
Humans
Image Interpretation, Computer-Assisted / methods*
Male
Metabolic Clearance Rate
Middle Aged
Models, Biological
Positron-Emission Tomography / methods*
Radiopharmaceuticals / pharmacokinetics
Receptor, Adenosine A1 / metabolism*
Tissue Distribution
Xanthines / pharmacokinetics*

Substances

1-methyl-8-dicyclopropylmethyl-1-methyl-3-propylxanthine
Radiopharmaceuticals
Receptor, Adenosine A1
Xanthines