Abstract
The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Neoplasms / metabolism
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Bone Neoplasms / radiotherapy*
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Feasibility Studies
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Femur / metabolism*
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Male
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Metabolic Clearance Rate
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Mice
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Mice, Inbred ICR
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Organ Specificity
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacokinetics*
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Organometallic Compounds / therapeutic use*
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Organophosphonates / chemistry
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Organophosphonates / pharmacokinetics*
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Organophosphonates / therapeutic use*
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / pharmacokinetics
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Radiopharmaceuticals / therapeutic use
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Tissue Distribution
Substances
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227Th-ethylenediamine-tetramethylenephosphonic acid
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Organometallic Compounds
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Organophosphonates
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Radiopharmaceuticals