Abstract
The aim of this study is to establish a method for quantitative measurement of histamine H(1) receptor (H1R) in human brain by PET and [(11)C]doxepin ([(11)C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [(11)C]DOX and PET can be evaluated with a two-compartment model.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Adult
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Algorithms
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Brain / diagnostic imaging*
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Brain / metabolism*
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Brain Mapping / methods
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Computer Simulation
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Doxepin / pharmacokinetics*
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Humans
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Image Interpretation, Computer-Assisted / methods*
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Male
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Metabolic Clearance Rate
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Models, Neurological*
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Positron-Emission Tomography / methods
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Radioisotope Dilution Technique
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Radiopharmaceuticals / pharmacokinetics
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Receptors, Histamine H1 / metabolism*
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Reproducibility of Results
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Sensitivity and Specificity
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Tissue Distribution
Substances
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Radiopharmaceuticals
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Receptors, Histamine H1
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Doxepin