Abstract
The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Base Sequence
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Carrier Proteins / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 15*
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DNA / genetics
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Dopamine Plasma Membrane Transport Proteins
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Humans
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Hybrid Cells
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In Situ Hybridization
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Molecular Sequence Data
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Nerve Tissue Proteins*
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Repetitive Sequences, Nucleic Acid
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Rodentia
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A3 protein, human
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DNA