Abstract
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Biomarkers, Tumor / metabolism*
-
Carrier Proteins / metabolism*
-
Folate Receptors, GPI-Anchored
-
Folic Acid / analogs & derivatives*
-
Folic Acid / pharmacokinetics*
-
Humans
-
Neoplasms / diagnostic imaging*
-
Neoplasms / metabolism*
-
Pentetic Acid / analogs & derivatives*
-
Pentetic Acid / pharmacokinetics*
-
Radioisotopes / pharmacokinetics
-
Radiopharmaceuticals / pharmacokinetics
-
Receptors, Cell Surface / metabolism*
-
Tomography, Emission-Computed / methods*
Substances
-
Biomarkers, Tumor
-
Carrier Proteins
-
DTPA folate
-
Folate Receptors, GPI-Anchored
-
Radioisotopes
-
Radiopharmaceuticals
-
Receptors, Cell Surface
-
Pentetic Acid
-
Folic Acid