Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature

Horm Res. 2003;60(4):205-8. doi: 10.1159/000073234.

Abstract

Aim: To describe the visualization of recurrent disease by [111In]octreotide and 201Tl scintigraphy in a patient with Hürthle cell thyroid carcinoma, increased thyroglobulin levels, and a negative radio-iodine total-body scan.

Methods: Scintigraphy with [111In]octreotide and 201Tl was performed, and a local recurrence in the thyroid bed was detected which was excised by surgery.

Results: On histology, the tumour proved to be a Hürthle cell carcinoma, and within the tumour somatostatin receptors were detected by RT-PCR.

Conclusion: Scintigraphy with [111In]octreotide and 201Tl is an alternative imaging method for the detection of residual disease in patients with a differentiated thyroid carcinoma having increased thyroglobulin levels and a negative radio-iodine total-body scan.

Publication types

  • Review

MeSH terms

  • Adenoma, Oxyphilic / diagnostic imaging*
  • Adenoma, Oxyphilic / surgery
  • Humans
  • Indium Radioisotopes*
  • Iodine Radioisotopes / pharmacokinetics
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Neoplasm Recurrence, Local / surgery
  • Octreotide*
  • Radionuclide Imaging
  • Receptors, Somatostatin / metabolism
  • Thallium Radioisotopes*
  • Thyroglobulin / analysis
  • Thyroid Neoplasms / diagnostic imaging*
  • Thyroid Neoplasms / surgery

Substances

  • Indium Radioisotopes
  • Iodine Radioisotopes
  • Receptors, Somatostatin
  • Thallium Radioisotopes
  • Thyroglobulin
  • Octreotide