Abstract
A fully automated preparation of S-(2-[(18)F]fluoroethyl)-L-methionine (FEMET), an amino acid tracer for tumor imaging with positron emission tomography, is described. [(18)F]F(-) was produced via nuclear reaction (18)O(p,n) [(18)F] at PETtrace Cyclotron. Direction nucleophilic fluorination reaction of [(18)F]fluoride with 1,2-di(4-methylphenylsulfonyloxy)ethane on a quaternary 4-(4-methylpiperidinyl)pyridinium functionalized polystyrene anion exchange resin gave 2-[(18)F]-1-(4-methylphenyl-sulfonyloxy)ethane, and then [(18)F]fluoroalkylation of L-homocysteine thiolactone with 2-[(18)F]-1-(4-methylphenylsulfonyloxy)ethane yielded FEMET. The overall radiochemical yield with no decay correction was about 10%, the whole synthesis time was about 52 min, and the radiochemical purity was above 95%.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, Ion Exchange / instrumentation
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Chromatography, Ion Exchange / methods*
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Ion Exchange Resins*
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Isotope Labeling / instrumentation
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Isotope Labeling / methods*
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Methionine / analogs & derivatives
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Methionine / chemical synthesis*
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Methionine / chemistry
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Methionine / isolation & purification
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Pyrimidines*
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / isolation & purification
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Reagent Kits, Diagnostic*
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Robotics / instrumentation
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Robotics / methods*
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Systems Integration
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Tomography, Emission-Computed / instrumentation
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Tomography, Emission-Computed / methods
Substances
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Ion Exchange Resins
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Pyrimidines
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Radiopharmaceuticals
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Reagent Kits, Diagnostic
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S-(2-fluoroethyl)methionine
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4-aminopyrimidine
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Methionine