Optical topography: practical problems and new applications

Appl Opt. 2003 Jun 1;42(16):3054-62. doi: 10.1364/ao.42.003054.

Abstract

We will briefly review the present status of optical topography and then discuss the method of improving practicality, i.e., the signal-to-noise (S/N) ratio and the spatial resolution in observations of higher-order brain functions. The optimum wavelength pair improved the S/N ratio sixfold for deoxyhemoglobin, and new configurations of light irradiation and detection positions doubled the spatial resolution. We also report on developing application fields of optical topography. This modality will bridge the gap between natural sciences, neuroscience, and pedagogy, and show actual real-time brain activity.

MeSH terms

  • Brain / physiology
  • Brain Mapping
  • Humans
  • Optics and Photonics*
  • Skin Physiological Phenomena
  • Tomography, X-Ray Computed / methods*