Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU

Nucl Med Biol. 2003 Apr;30(3):215-24. doi: 10.1016/s0969-8051(02)00445-6.

Abstract

An efficient and reliable synthesis of 2'-deoxy-2'-[(18)F]fluoro-beta-D-arabinofuranosyl nucleosides is presented. Overall decay-corrected radiochemical yields of 35-45% of 4 analogs, FAU, FMAU, FBAU and FIAU are routinely obtained in >98% radiochemical purity and with specific activities of greater than 3 Ci/micromol (110 MBq/micromol) in a synthesis time of approximately 3 hours. When approximately 220 mCi (8.15 GBq) of starting [(18)F]fluoride is used, 25 -30 mCi (0.93 -1.11 GBq) of product (enough to image two patients sequentially) is typically obtained.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Arabinofuranosyluracil / analogs & derivatives*
  • Arabinofuranosyluracil / chemical synthesis
  • Arabinofuranosyluracil / chemistry
  • Arabinonucleosides / chemical synthesis*
  • Arabinonucleosides / chemistry
  • Fluorine Radioisotopes

Substances

  • 2'-fluorodeoxyuracil-arabinofuranoside
  • Antiviral Agents
  • Arabinonucleosides
  • Fluorine Radioisotopes
  • Arabinofuranosyluracil
  • fialuridine
  • clevudine