Structural variety of membrane permeable peptides

Shiroh Futaki; Susumu Goto; Tomoki Suzuki; Ikuhiko Nakase; Yukio Sugiura

doi:10.2174/1389203033487261

Structural variety of membrane permeable peptides

Curr Protein Pept Sci. 2003 Apr;4(2):87-96. doi: 10.2174/1389203033487261.

Authors

Shiroh Futaki¹, Susumu Goto, Tomoki Suzuki, Ikuhiko Nakase, Yukio Sugiura

Affiliation

¹ Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. futaki@scl.kyoto-u.ac.jp

PMID: 12678848
DOI: 10.2174/1389203033487261

Abstract

Peptide-mediated protein delivery into living cells has been attracting our attention. Among the peptides that have been reported to have carrier activity, the one from the human immunodeficient virus (HIV)-1 Tat has been most often used for the introduction of exogenous macromolecules into cells. We have shown that not only the Tat peptide, but also various arginine-rich peptides showed very similar characteristics in translocation, and the possible presence of ubiquitous internalization mechanisms among the arginine-rich peptides has also been suggested. These arginine-rich peptides includes ones derived from HIV-1 Rev and flock house virus coat proteins. The linear- and branched-chain peptides containing approximately 8 residues of arginine also show a similar ability. In this review, we present the structural variety of membrane permeable peptides and provide a survey of the findings on the translocation of these peptides through the cell membranes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Amino Acids, Branched-Chain / chemistry
Amino Acids, Branched-Chain / metabolism
Animals
Arginine / chemistry*
Arginine / metabolism*
Cell Membrane Permeability*
Gene Products, rev / chemical synthesis
Gene Products, rev / chemistry
Gene Products, rev / metabolism
Gene Products, tat / chemistry
Gene Products, tat / metabolism
HIV-1 / chemistry
HIV-1 / metabolism
HeLa Cells
Humans
Peptide Fragments / chemistry
Peptide Fragments / metabolism
Peptides / chemical synthesis
Peptides / chemistry*
Peptides / classification
Peptides / metabolism*
Protein Transport*
Structure-Activity Relationship
rev Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus

Substances

Amino Acids, Branched-Chain
Gene Products, rev
Gene Products, tat
Peptide Fragments
Peptides
rev Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
tat peptide (48-60), Human immunodeficiency virus 1
Arginine