PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling

Cancer Treat Res. 2003:115:145-67.

Authors

Juan Paez¹, William R Sellers

Affiliation

¹ Department of Adult Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 12613196

No abstract available

Publication types

Review

MeSH terms

Animals
Humans
Neoplasms / metabolism*
Neoplasms / pathology
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases / physiology*
Phosphoric Monoester Hydrolases / physiology*
Protein Serine-Threonine Kinases*
Proto-Oncogene Proteins / physiology*
Proto-Oncogene Proteins c-akt
Signal Transduction*
Tumor Suppressor Proteins / physiology*

Substances

Proto-Oncogene Proteins
Tumor Suppressor Proteins
AKT1 protein, human
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Phosphoric Monoester Hydrolases
PTEN Phosphohydrolase
PTEN protein, human