Complexation of VEGF with bevacizumab decreases VEGF clearance in rats

Pharm Res. 2002 Nov;19(11):1753-6. doi: 10.1023/a:1020778001267.
No abstract available

MeSH terms

  • Angiogenesis Inducing Agents / administration & dosage
  • Angiogenesis Inducing Agents / blood
  • Angiogenesis Inducing Agents / metabolism*
  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / metabolism*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Chemistry, Pharmaceutical
  • Female
  • Humans
  • Male
  • Metabolic Clearance Rate / drug effects
  • Metabolic Clearance Rate / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Vascular Endothelial Growth Factor A*

Substances

  • Angiogenesis Inducing Agents
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab