Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests

Héric Valette; Frédéric Dollé; Michel Bottlaender; Françoise Hinnen; Daniel Marzin

doi:10.1016/s0969-8051(02)00331-1

Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests

Nucl Med Biol. 2002 Nov;29(8):849-53. doi: 10.1016/s0969-8051(02)00331-1.

Authors

Héric Valette¹, Frédéric Dollé, Michel Bottlaender, Françoise Hinnen, Daniel Marzin

Affiliation

¹ Service Hospitalier Frédéric Joliot, CEA, DSV/DRM, 4 Place du Général Leclerc, F-91406, Orsay, France. valette@shfj.cea.fr

PMID: 12453596
DOI: 10.1016/s0969-8051(02)00331-1

Abstract

The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychromatic erythrocytes was found in animals treated at any dose tested. No biologically significant increase in the mean number of revertants was noted in all the Salmonella typhimurium strains tested with fluoro-A-85380. Therefore, fluoro-A-85380 demonstrated no mutagenic properties using these two tests.

Publication types

Comparative Study
Evaluation Study

MeSH terms

Animals
Azetidines / adverse effects*
Bone Marrow Cells
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical / methods
Erythrocytes, Abnormal / drug effects
Erythrocytes, Abnormal / pathology
Female
Male
Micronucleus Tests / methods*
Mutagenesis / drug effects*
Mutagenicity Tests / methods*
Pyridines / adverse effects*
Rats
Rats, Sprague-Dawley
Reference Values
Salmonella typhimurium / drug effects*
Salmonella typhimurium / genetics

Substances

2-fluoro-3-(2-azetidinylmethoxy)pyridine
Azetidines
Pyridines