Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate)

AJR Am J Roentgenol. 2002 Oct;179(4):1059-62. doi: 10.2214/ajr.179.4.1791059.

Abstract

Objective: The purpose of this article is to illustrate the CT findings in patients with hepatic metastases from a gastrointestinal stromal tumor who were treated with STI-571.

Conclusion: Hepatic metastases from gastrointestinal stromal tumors that respond to treatment with STI-571 can appear as near-cystic components with well-defined borders on contrast-enhanced CT. Most metastases became smaller. These metastases resemble simple cysts, but density measurements may differentiate them from one another.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Cysts / diagnostic imaging
  • Enzyme Inhibitors / therapeutic use*
  • Female
  • Gastrointestinal Neoplasms / pathology*
  • Humans
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary*
  • Male
  • Middle Aged
  • Omentum
  • Peritoneal Neoplasms / pathology
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Stomach Neoplasms / pathology
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein-Tyrosine Kinases