Multiple myeloma: evolving genetic events and host interactions

Nat Rev Cancer. 2002 Mar;2(3):175-87. doi: 10.1038/nrc746.

Abstract

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?

Publication types

  • Review

MeSH terms

  • B-Lymphocytes / physiology
  • Enhancer Elements, Genetic
  • Humans
  • Immunoglobulins / genetics
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / pathology
  • Neoplasm Staging
  • Oncogenes
  • Translocation, Genetic

Substances

  • Immunoglobulins