Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer

Y-S Lee; J M Jeong; Y J Kim; J W Chung; J H Park; Y-G Suh; D S Lee; J-K Chung; M C Lee

doi:10.1097/00006231-200203000-00006

Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer

Nucl Med Commun. 2002 Mar;23(3):237-42. doi: 10.1097/00006231-200203000-00006.

Authors

Y-S Lee¹, J M Jeong, Y J Kim, J W Chung, J H Park, Y-G Suh, D S Lee, J-K Chung, M C Lee

Affiliation

¹ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.

PMID: 11891481
DOI: 10.1097/00006231-200203000-00006

Abstract

Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Iodized Oil / pharmacokinetics*
Liver Neoplasms / metabolism*
Liver Neoplasms / radiotherapy
Lung / metabolism
Mice
Mice, Inbred ICR
Organometallic Compounds / chemical synthesis*
Organometallic Compounds / pharmacokinetics*
Organometallic Compounds / therapeutic use
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / pharmacokinetics*
Radiopharmaceuticals / therapeutic use
Tissue Distribution

Substances

Organometallic Compounds
Radiopharmaceuticals
rhenium diaminedithiol
Iodized Oil