[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5

Fabrizio Gasparini; Hendrik Andres; Peter Josef Flor; Micheline Heinrich; Werner Inderbitzin; Kurt Lingenhöhl; Hanspeter Müller; Veronica Cecilia Munk; Kyla Omilusik; Christine Stierlin; Natacha Stoehr; Ivo Vranesic; Rainer Kuhn

doi:10.1016/s0960-894x(01)00767-3

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5

Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9. doi: 10.1016/s0960-894x(01)00767-3.

Authors

Fabrizio Gasparini¹, Hendrik Andres, Peter Josef Flor, Micheline Heinrich, Werner Inderbitzin, Kurt Lingenhöhl, Hanspeter Müller, Veronica Cecilia Munk, Kyla Omilusik, Christine Stierlin, Natacha Stoehr, Ivo Vranesic, Rainer Kuhn

Affiliation

¹ Nervous System Research, Novartis Pharma AG, 4002 Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com

PMID: 11814808
DOI: 10.1016/s0960-894x(01)00767-3

Abstract

The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.

MeSH terms

Binding Sites
Binding, Competitive / drug effects
Humans
Kinetics
Ligands
Pyridines / pharmacology*
Radiopharmaceuticals / chemical synthesis*
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate / antagonists & inhibitors
Receptors, Metabotropic Glutamate / metabolism*
Recombinant Proteins / metabolism

Substances

Ligands
Pyridines
Radiopharmaceuticals
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate
Recombinant Proteins
SIB 1893
6-methyl-2-(phenylethynyl)pyridine