Abstract
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alzheimer Disease / diagnostic imaging
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Amyloid / metabolism*
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Animals
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Benzothiazoles
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Binding, Competitive / drug effects
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Brain / diagnostic imaging*
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Chemical Phenomena
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Chemistry, Physical
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Mice
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Mice, Transgenic
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Microscopy
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Plaque, Amyloid / diagnostic imaging*
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / chemistry*
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Structure-Activity Relationship
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Thiazoles / chemical synthesis
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Thiazoles / chemistry*
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Tomography, Emission-Computed
Substances
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Amyloid
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Benzothiazoles
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Radiopharmaceuticals
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Thiazoles
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thioflavin T