Abstract
[reaction: see text] A general strategy for the functional diversification of DNA oligonucleotides under physiological conditions was developed. We describe the synthesis of DNA molecules bearing ketone ports (ketone-DNA) and the efficient postsynthetic decoration of ketone-DNA with structurally diverse aminooxy compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Chromatography, High Pressure Liquid
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Circular Dichroism
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DNA / chemistry*
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Ketones / chemistry*
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Molecular Structure
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Nucleic Acid Denaturation
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Oligodeoxyribonucleotides / chemical synthesis
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Oligodeoxyribonucleotides / chemistry*
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Oligopeptides / chemistry
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Antineoplastic Agents
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Ketones
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Oligodeoxyribonucleotides
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Oligopeptides
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arginyl-glycyl-aspartic acid
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DNA