Imaging transgenic animals

T F Budinger; D A Benaron; A P Koretsky

doi:10.1146/annurev.bioeng.1.1.611

Imaging transgenic animals

Annu Rev Biomed Eng. 1999:1:611-48. doi: 10.1146/annurev.bioeng.1.1.611.

Authors

T F Budinger¹, D A Benaron, A P Koretsky

Affiliation

¹ Department of Bioengineering and Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

PMID: 11701502
DOI: 10.1146/annurev.bioeng.1.1.611

Abstract

Transgenic and eugenic animals as small as 30 g can be studied non-invasively by radionuclides with resolutions of 1-2 mm, by MRI with resolution of 100 microns and by light fluorescence and bioluminescence with high sensitivities. The technologies of radionuclide emission, magnetic resonance imaging, magnetic resonance spectroscopy, optical tomography, optical fluorescence and optical bioluminescence are currently being applied to small-animal studies. These technologies and examples of their applications are reviewed in this chapter.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Animals, Genetically Modified / anatomy & histology*
Animals, Genetically Modified / genetics
Biomedical Engineering
Diagnostic Imaging*
Gated Blood-Pool Imaging
Luminescent Measurements
Magnetic Resonance Imaging
Mice
Mice, Transgenic
Rats
Spectrometry, Fluorescence
Spectroscopy, Near-Infrared
Tomography
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon