A 212Pb generator based on a 228Th source

Appl Radiat Isot. 2001 Oct;55(4):433-9. doi: 10.1016/s0969-8043(00)00372-9.

Abstract

A two-compartment 212Pb generator has been constructed and characterized physically and chemically. It is based on transport by airflow of gaseous 220Rn emanating from thin layers of [228Th]barium stearate. 220Rn is collected in a glass bubbler by extraction into an organic solvent and solidified at temperatures below -72 degrees C. Tracer studies show that the decay product 212Pb can be recovered with approximately 70% yield. It is suggested that this generator design could accommodate therapeutic levels of 212Pb/228Th.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Humans
  • Lead Radioisotopes / isolation & purification*
  • Lead Radioisotopes / therapeutic use
  • Neoplasms / radiotherapy
  • Radiopharmaceuticals / isolation & purification
  • Radiopharmaceuticals / therapeutic use
  • Radon / isolation & purification
  • Thorium*

Substances

  • Lead Radioisotopes
  • Radiopharmaceuticals
  • Thorium
  • Radon