The structure of McN-5652

Bioorg Med Chem. 2001 Aug;9(8):2105-11. doi: 10.1016/s0968-0896(01)00117-1.

Abstract

The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Crystallography, X-Ray
  • Isoquinolines / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Serotonin Antagonists / chemistry*

Substances

  • Isoquinolines
  • Serotonin Antagonists
  • McN 5652