Abstract
The effect of ageing on brain serotonin transporters was evaluated in 19 healthy female volunteers (age range 22-74 years) using single-photon emission tomography and [123I]nor-beta-CIT. The study subjects were scanned 0.3, 3, 6 and 23 h after injection of 185 MBq of [123I]nor-beta-CIT. The ratio of the distribution volume for tracer in the midbrain to that in the cerebellum minus 1 was used as an index for serotonin transporter binding. An age-related decline of 2% per decade (r=-0.47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade).
MeSH terms
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Adult
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Aged
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Aging / metabolism*
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Brain / metabolism*
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Carrier Proteins / analysis*
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Cerebellum / metabolism
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Cocaine / analogs & derivatives*
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Female
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Humans
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Iodine Radioisotopes
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Membrane Glycoproteins / analysis*
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Membrane Transport Proteins*
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Mesencephalon / metabolism
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Middle Aged
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Nerve Tissue Proteins*
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Radiopharmaceuticals
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Reference Values
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Serotonin / analysis*
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Serotonin Plasma Membrane Transport Proteins
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Sex Characteristics*
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Tomography, Emission-Computed, Single-Photon*
Substances
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Carrier Proteins
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Iodine Radioisotopes
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Radiopharmaceuticals
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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N-nor-3-(4'-iodophenyl)tropane-2-carboxylic acid methyl ester
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Serotonin
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Cocaine