Abstract
Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.
MeSH terms
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Antidepressive Agents / pharmacology
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Antidepressive Agents / therapeutic use
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Cell Survival / drug effects
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Depressive Disorder / drug therapy
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Depressive Disorder / metabolism
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Depressive Disorder / pathology*
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Glucocorticoids / pharmacology
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Neuronal Plasticity / drug effects
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Signal Transduction
Substances
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Antidepressive Agents
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Glucocorticoids