Abstract
The transport and accumulation of free 211At and 125I- were investigated in thyrocytes cultured as monolayers in bicameral chambers under the influence of thyroid-stimulating hormone, stable iodide, ouabain and perchlorate. The results indicate that there are similarities and differences in the transport mechanisms of free 211At and 125I-. These results will be valuable in the development of radiation protection when handling and using 211At-labeled radiopharmaceuticals, and for the potential use of free 211At in radiation therapy of poorly differentiated thyroid cancer.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Astatine / pharmacokinetics*
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Biological Transport / drug effects
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Cell Culture Techniques / instrumentation
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Cell Culture Techniques / methods
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Cells, Cultured
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Enzyme Inhibitors / pharmacology
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Epithelium / drug effects
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Epithelium / metabolism
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Iodine Radioisotopes / pharmacokinetics*
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Ouabain / pharmacology
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Perchlorates / pharmacology
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Sodium Compounds / pharmacology
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Swine
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Thyroid Gland / drug effects
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Thyroid Gland / metabolism*
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Thyrotropin / pharmacology
Substances
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Enzyme Inhibitors
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Iodine Radioisotopes
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Perchlorates
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Sodium Compounds
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Ouabain
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Thyrotropin
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sodium perchlorate
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Astatine