Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid [correction of diethylenetetraminepentaacetic acid]

D T Corson; C F Meares

doi:10.1021/bc990125x

Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid [correction of diethylenetetraminepentaacetic acid]

Bioconjug Chem. 2000 Mar-Apr;11(2):292-9. doi: 10.1021/bc990125x.

Authors

D T Corson¹, C F Meares

Affiliation

¹ Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616-5295, USA.

PMID: 10725108
DOI: 10.1021/bc990125x

Abstract

We have developed and optimized the synthesis of the title compound, eliminating all HPLC purifications prior to the final product. The yield (and scale) of the synthesis was increased from 19% (200 mg) to 75% (26 g).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal / chemistry
Chelating Agents / chemical synthesis
Chelating Agents / chemistry*
Chromatography, High Pressure Liquid
Drug Carriers / chemical synthesis*
Humans
Hydrogen-Ion Concentration
Pentetic Acid / analogs & derivatives*
Pentetic Acid / chemical synthesis
Pentetic Acid / chemistry
Solvents

Substances

Antibodies, Monoclonal
Chelating Agents
Drug Carriers
Solvents
1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid
Pentetic Acid