Abstract
Dopamine reuptake transporter binding kinetics of 2beta-carbomethoxy-3beta-(4-[18F]fluoromethylphenyl)tropane (p-FWIN) and 2beta-carbomethoxy-3beta-(2-[18F]fluoromethylphenyl)tropane (o-FWIN) were determined in vervet monkeys using positron emission tomography (PET). Ligand localization was rapid and specific to the striatum with kinetic estimates comparable with those of 11C-labeled WIN 35,428 (CWIN). Binding was more specific with p-FWIN than with CWIN or o-FWIN. The relatively longer half-life of the 18F radiolabel enabled longer acquisition times with p-FWIN, resulting in less variability in the kinetic estimates.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Brain / diagnostic imaging
-
Brain Chemistry*
-
Carrier Proteins / metabolism*
-
Chlorocebus aethiops
-
Cocaine / analogs & derivatives
-
Cocaine / pharmacokinetics
-
Dopamine Plasma Membrane Transport Proteins
-
Dopamine Uptake Inhibitors / pharmacokinetics
-
Image Processing, Computer-Assisted
-
Ligands
-
Membrane Glycoproteins*
-
Membrane Transport Proteins*
-
Nerve Tissue Proteins*
-
Norepinephrine / metabolism
-
Radiopharmaceuticals / chemical synthesis*
-
Radiopharmaceuticals / pharmacokinetics
-
Radiopharmaceuticals / pharmacology
-
Rats
-
Rats, Sprague-Dawley
-
Receptors, Dopamine / metabolism*
-
Serotonin / metabolism
-
Tomography, Emission-Computed
-
Tropanes / chemical synthesis*
-
Tropanes / pharmacokinetics
-
Tropanes / pharmacology
Substances
-
2-carbomethoxy-3-(2-fluoromethylphenyl)tropane
-
2-carbomethoxy-3-(4-fluoromethylphenyl)tropane
-
Carrier Proteins
-
Dopamine Plasma Membrane Transport Proteins
-
Dopamine Uptake Inhibitors
-
Ligands
-
Membrane Glycoproteins
-
Membrane Transport Proteins
-
Nerve Tissue Proteins
-
Radiopharmaceuticals
-
Receptors, Dopamine
-
Tropanes
-
Serotonin
-
(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester
-
Cocaine
-
Norepinephrine