Abstract
To explore the mechanisms underlying L-dopa response, we studied, by postmortem autoradiography, selective makers of dopamine presynaptic terminals, [3H]WIN 35428, and dopamine D2 receptors, [3H]nemonapride, in the putamen of four Parkinson's disease (PD) and one striatonigral degeneration (SND) neuropathologically confirmed brains as compared with six matched control brains. Dopamine uptake transporter was dramatically decreased (> 90%) both in PD and SND striatum. Dopamine D2 receptors were preserved in PD, but clearly reduced (> 76%) in the SND putamen. These data confirm that L-dopa response is closely associated with the preservation of striatal dopamine D2 receptors.
MeSH terms
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Aged
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Autoradiography
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Benzamides / metabolism
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Cadaver
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Carrier Proteins / metabolism*
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Cocaine / analogs & derivatives
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Cocaine / metabolism
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Corpus Striatum / metabolism
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Dopamine Antagonists / metabolism
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Dopamine Plasma Membrane Transport Proteins
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Dopamine Uptake Inhibitors / metabolism
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Female
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Humans
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Male
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Membrane Glycoproteins*
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Membrane Transport Proteins*
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Middle Aged
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Nerve Tissue Proteins*
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Parkinson Disease / metabolism
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Putamen / metabolism
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Receptors, Dopamine D2 / metabolism*
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Reference Values
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Striatonigral Degeneration / metabolism*
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Striatonigral Degeneration / pathology
Substances
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Benzamides
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Carrier Proteins
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Dopamine Antagonists
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Dopamine Plasma Membrane Transport Proteins
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Dopamine Uptake Inhibitors
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Receptors, Dopamine D2
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(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester
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Cocaine
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nemonapride