Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration

Brain Res. 2000 Jan 3;852(1):228-32. doi: 10.1016/s0006-8993(99)02205-2.

Abstract

To explore the mechanisms underlying L-dopa response, we studied, by postmortem autoradiography, selective makers of dopamine presynaptic terminals, [3H]WIN 35428, and dopamine D2 receptors, [3H]nemonapride, in the putamen of four Parkinson's disease (PD) and one striatonigral degeneration (SND) neuropathologically confirmed brains as compared with six matched control brains. Dopamine uptake transporter was dramatically decreased (> 90%) both in PD and SND striatum. Dopamine D2 receptors were preserved in PD, but clearly reduced (> 76%) in the SND putamen. These data confirm that L-dopa response is closely associated with the preservation of striatal dopamine D2 receptors.

MeSH terms

  • Aged
  • Autoradiography
  • Benzamides / metabolism
  • Cadaver
  • Carrier Proteins / metabolism*
  • Cocaine / analogs & derivatives
  • Cocaine / metabolism
  • Corpus Striatum / metabolism
  • Dopamine Antagonists / metabolism
  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine Uptake Inhibitors / metabolism
  • Female
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Middle Aged
  • Nerve Tissue Proteins*
  • Parkinson Disease / metabolism
  • Putamen / metabolism
  • Receptors, Dopamine D2 / metabolism*
  • Reference Values
  • Striatonigral Degeneration / metabolism*
  • Striatonigral Degeneration / pathology

Substances

  • Benzamides
  • Carrier Proteins
  • Dopamine Antagonists
  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine Uptake Inhibitors
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Receptors, Dopamine D2
  • (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester
  • Cocaine
  • nemonapride