[11C]-methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors

Nucl Med Biol. 1999 Oct;26(7):737-41. doi: 10.1016/s0969-8051(99)00043-8.

Abstract

GR89696, racemic methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl) methyl]-1-piperazinecarboxylate, a kappa opioid receptor ligand, was labeled with [11C]methyl chloroformate. The radiochemical yield was 20% with an observed specific radioactivity of 75.5 GBq/micromol at end of synthesis (2,040 mCi/micromol). Five minutes after intravenous administration, 5.4% of the injected dose accumulated in mouse whole brain. Brain region to cerebellar ratios increased over time with ratios at 90 min of 7.8, 5.6, and 4.5 for the hypothalamus, olfactory tubercle, and striatum, respectively. The uptake of [11C]GR89696 correlated with known kappa opioid receptor densities and was inhibited by kappa opioid selective drugs.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzeneacetamides*
  • Binding, Competitive
  • Brain / metabolism
  • Carbon Radioisotopes / chemistry
  • Dopamine Antagonists / metabolism
  • Dopamine Antagonists / pharmacology
  • Isotope Labeling
  • Ketanserin / metabolism
  • Ketanserin / pharmacology
  • Mice
  • Piperazines / chemical synthesis*
  • Piperazines / isolation & purification
  • Piperazines / metabolism*
  • Piperazines / pharmacokinetics
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / isolation & purification
  • Pyrrolidines / metabolism*
  • Pyrrolidines / pharmacokinetics
  • Pyrrolidines / pharmacology
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / isolation & purification
  • Radiopharmaceuticals / metabolism*
  • Radiopharmaceuticals / pharmacokinetics
  • Receptors, Opioid, kappa / agonists
  • Receptors, Opioid, kappa / antagonists & inhibitors
  • Receptors, Opioid, kappa / metabolism*
  • Serotonin Antagonists / metabolism
  • Serotonin Antagonists / pharmacology
  • Spiperone / metabolism
  • Spiperone / pharmacology
  • Tissue Distribution

Substances

  • Benzeneacetamides
  • Carbon Radioisotopes
  • Dopamine Antagonists
  • Piperazines
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Opioid, kappa
  • Serotonin Antagonists
  • GR 89696
  • Spiperone
  • Ketanserin
  • U 69593