Abstract
We present a case of increased I-131 uptake in a patient with papillary thyroid carcinoma with local recurrence and distant metastases after a second treatment with retinoic acid as a sign of redifferentiation of the tumor cells. When fine-needle aspiration cytology before and after a second course of retinoic acid treatment were compared, signs of tumor cell redifferentiation were found. This was accompanied by biochemical reexpression of thyroid marker proteins.
MeSH terms
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Carcinoma, Papillary / diagnostic imaging
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Carcinoma, Papillary / pathology
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Carcinoma, Papillary / secondary
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Carcinoma, Papillary / therapy*
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Humans
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Iodine Radioisotopes / therapeutic use*
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Isotretinoin / therapeutic use*
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / secondary
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Lung Neoplasms / therapy
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Male
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Middle Aged
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Neoplasm Recurrence, Local / diagnostic imaging
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / therapy*
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Radionuclide Imaging
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Thyroid Neoplasms / diagnostic imaging
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Thyroid Neoplasms / pathology
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Thyroid Neoplasms / therapy*
Substances
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Iodine Radioisotopes
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Isotretinoin