Abstract
The anticonvulsant mood stabilizers valproic acid (250, 500 but not 50 mg/kg) and carbamazepine (6, 12.5 but not 3 mg/kg) were found to increase extracellular dopamine levels in rat medial prefrontal cortex, but not nucleus accumbens. Increased prefrontal dopamine was completely abolished by the selective 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexa necarboxamide (WAY100635, 0.05 mg/kg). Anticonvulsants and clozapine may share a common mood stabilizing mechanism since clozapine is reported to have mood stabilizing effects and increase prefrontal dopamine by 5-HT1A receptor activation.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / pharmacology*
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Carbamazepine / pharmacology*
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Dopamine / metabolism*
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Dose-Response Relationship, Drug
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Piperazines / pharmacology
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Prefrontal Cortex / drug effects*
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Prefrontal Cortex / metabolism
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Pyridines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists / pharmacology
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Valproic Acid / pharmacology*
Substances
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Anticonvulsants
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Piperazines
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Pyridines
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Antagonists
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Carbamazepine
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Valproic Acid
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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Dopamine