The purpose of this study was to compare the image quality for a digital storage phosphor system using 1760 x 2140 (2k) and 3520 x 4280 (4k) image arrays. Measurements were made on a chest radiography system (Fuji FCR-9501) with special provisions to be operated in both 2k (standard) and 4k (HQ) modes. Presampled modulation transfer functions (MTF) were measured using an edge method. Noise power spectra (NPS) were determined for different input exposures by two-dimensional Fourier analysis. These measures along with exposure measurements and an x-ray spectral model were used to determine the frequency-dependent detective quantum efficiency DQE (f) of the system for the 4k and the 2k modes. The magnitude of the NPS for the 4k mode was about 1/2 that of the 2k mode. A MTF value of 0.5 was found at 1.25 cycles/mm for the 4k system and 1.50 cycles/mm for the 2k system. The 4k images had an extended MTF of 0.1 at 4.5 cycles/mm in the plate-scan direction. Overall, the DQE (f) of the 4k mode was slightly better than that for the 2k mode by about 0.02 due primarily to its better noise characteristics.