Abstract
A 69-year-old man had hypothyroid dementia as a result of I-131 therapy and an overdose of methimazole. Tc-99m HMPAO SPECT revealed diffuse cerebral hypoperfusion. The findings of brain SPECT normalized with the disappearance of symptoms and a return to the euthyroid state. There was a 25% or 26% reduction of the mean cerebral blood flow during dementia. This may be the first report in which SPECT brain imaging revealed reversible hypoperfusion associated with reversible hypothyroid dementia.
MeSH terms
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Aged
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Antithyroid Agents / adverse effects*
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Brain / diagnostic imaging
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Cerebrovascular Circulation
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Dementia / diagnostic imaging
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Dementia / etiology*
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Graves Disease / radiotherapy*
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Humans
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Hypothyroidism / complications*
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Hypothyroidism / etiology
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Iodine Radioisotopes / adverse effects*
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Male
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Methimazole / adverse effects*
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Radiopharmaceuticals*
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Technetium Tc 99m Exametazime*
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Tomography, Emission-Computed, Single-Photon*
Substances
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Antithyroid Agents
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Iodine Radioisotopes
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Radiopharmaceuticals
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Technetium Tc 99m Exametazime
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Methimazole