Abstract
Selective radiolabelling and imaging of transduced HSV tk expressing cells was studied using [123I]IVFRU, [125I]FIRU and [125I]FIAU. Although all three radionucleosides accumulated in the KBALB-STK transduced murine tumour line in vitro and in vivo, [125I]FIRU provided optimal performance in terms of selectivity for HSV tk expressing cells and % of injected dose accumulating in the tumor.
MeSH terms
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Animals
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Genetic Therapy*
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Herpesvirus 1, Human / enzymology*
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Iodine Radioisotopes
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Male
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Mice
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Mice, Inbred BALB C
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Neoplasm Transplantation
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / therapy*
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Pyrimidine Nucleosides / metabolism*
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Thymidine Kinase / genetics*
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Tissue Distribution
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Tumor Cells, Cultured
Substances
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Iodine Radioisotopes
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Pyrimidine Nucleosides
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Thymidine Kinase