The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE STRUCTURE OF PA48009: THE REVISED STRUCTURE OF DURAMYCIN
FUMIAKI HAYASHI, KAZUO NAGASHIMA, YOSHIHIRO TERUI, YOSHIMI KAWAMURA, KOICHI MATSUMOTO, HIROSHI ITAZAKI
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1990 Volume 43 Issue 11 Pages 1421-1430

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Abstract

PA48009, a lanthionine-containing peptide antibiotic was isolated from the culture broth of Streptoverticillium griseoverticillatum PA-48009, and identified as duramycin. Determination of the structure using both Edman degradations and 2D NMR spectroscopy showed the need to revise the structure of duramycin given in literature. Duramycin (PA48009) was different from lanthiopeptin (Ro 09-0198, cinnamycin) only by a Lys/Arg exchange at position 2.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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