Elsevier

Poultry Science

Volume 58, Issue 4, 1 July 1979, Pages 988-990
Poultry Science

Research Notes
Effects of Furazolidone in the Early Chick Embryo1

https://doi.org/10.3382/ps.0580988Get rights and content
Under a Creative Commons license
open access

Abstract

Effects of furazolidone in early chick embryos were investigated in order to determine the feasibility of using this biological system as a model for studying the mechanism(s) of furazolidone toxicity.

Double and triple injections of varying dosages of furazolidone were administered via the yolk sac at early stages of incubation. Toxic levels of the drug affecting both growth and levels of glycogen were dosage-dependent and time-dependent. Double injections of furazolidone at a dose as little as 60 μg/egg administered at 40 and 72 hr of incubation significantly retarded growth (P<.001) and increased glycogen levels (P<.05) in the embryo and yolk sac. Mortality was high in embryos receiving toxic levels of furazolidone, but no gross abnormalities were observed.

Cited by (0)

1

This work formed part of a thesis submitted by the junior author in partial fulfillment of the requirements for the Master of Science Degree in Veterinary Anatomy, University of Minnesota.

2

Permanent address: Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 9, Thailand.