Stevens-Johnson Syndrome Associated With Intravenous Acetazolamide Administration for Evaluation of Cerebrovascular Reactivity —Case Report—

Kuniaki OGASAWARA; Nobuhiko TOMITSUKA; Masakazu KOBAYASHI; Nobukazu KOMORIBAYASHI; Takeshi FUKUDA; Hideo SAITOH; Takashi INOUE; Akira OGAWA

doi:10.2176/nmc.46.161

Case Reports

Stevens-Johnson Syndrome Associated With Intravenous Acetazolamide Administration for Evaluation of Cerebrovascular Reactivity

—Case Report—

Kuniaki OGASAWARA, Nobuhiko TOMITSUKA, Masakazu KOBAYASHI, Nobukazu KOMORIBAYASHI, Takeshi FUKUDA, Hideo SAITOH, Takashi INOUE, Akira OGAWA

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Keywords: acetazolamide, cerebrovascular reactivity, Stevens-Johnson syndrome

JOURNAL OPEN ACCESS

2006 Volume 46 Issue 3 Pages 161-163

DOI https://doi.org/10.2176/nmc.46.161

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Abstract

A 62-year-old man with left middle cerebral artery stenosis manifesting as transient ischemic attack underwent evaluation of regional cerebrovascular reactivity to acetazolamide using single photon emission computed tomography. Three days after intravenous administration of acetazolamide, erythematous eruptions of various sizes appeared on his back and spread over almost his entire body. Subsequently, painful ulcerations developed on his lips, and oral and nasal mucosa, and the conjunctiva became hyperemic, indicating Stevens-Johnson syndrome. The results of the lymphocyte transformation test were positive to only acetazolamide. Stevens-Johnson syndrome, also known as erythema multiforme major, can be life-threatening, and may be induced by intravenous administration of acetazolamide.

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