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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Translational Molecular Imaging in Drug Development: Current Status and Challenges

Author(s): Mei Tian and Michael J. Welch

Volume 6, Issue 1, 2010

Page: [51 - 55] Pages: 5

DOI: 10.2174/157340510790693947

Price: $65

Abstract

Molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems. In the past decade, there has been sufficient experience with specifically targeted therapeutic or diagnostic imaging agents that we must begin moving them from bench to bedside. However, crucial prerequisites for the development of safe pre-clinical protocols in molecular imaging research are needed through suitable large animal models since most of previous experiments were carried out on rodents. This review is focus on the translational molecular imaging research on drug development and radiopharmaceutical drug development, animal model selection, experimental design, the obstacle and future challenges of translational molecular imaging.

Keywords: Translational medicine, imaging, investigational new drugs, animal model


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